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CD4+ T cell fate in multiple myeloma

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA658707
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资源简介:
The average age of onset of multiple myeloma (MM) is in the 7th decade coinciding with the development of immunosenescence. As a consequence, lymphocyte recovery after lymphopenia-inducing anti-MM therapies (most notably autologous stem cell transplant) is reliant on homeostatic proliferation of peripheral T cells rather than replenishment by new thymic emigrants. Knowing the phenotypic changes in the T cell population over the course of disease, RNAseq was utilised to analyse the genotypic changes in order to further explore the fate of CD4+ T cells in MM with disease progression.
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2020-08-23
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