Therapeutic Potential of Probiotic Nanosilver Composite in Modulating Gut Homeostasis through Wnt Pathway and Chemokine Receptor Signaling in TNBS Induced Colitis in Murine Models

This project developed a probiotic-silver nanocomposite as a multi-targeted therapy for inflammatory bowel disease (IBD). In a colitis model, the treatment improved survival and intestinal repair by simultaneously modulating gut microbiota, reducing inflammation via CCR2 inhibition, and activating the Wnt/beta-catenin pathway to regenerate the epithelial barrier. This integrated strategy promotes immune and barrier homeostasis in IBD.