Values for the calculation of the time-dependent drug concentrations in the system based on observed data found and derived from a variety of sources.

Sources listed respective to imatinib, ponatinib, and dasatinib. Absorption constants, ka, were taken from [68], [69], and [70]. The elimination half-lifes, , that the elimination constants, ke, were calculated from are from [65], [71], and [72]. For the dose, D, we chose masses described as daily doses in“typical treatment” [73], [69], and [74]. The volumes of distribution, Vd, were taken from [65], [75], and [72]. Values for Γ, α and ε were calculated using Eqs 21–23.