Comparison between previous study and this GWAS for CCR3 gene's association with AAM.

1The second allele represents the minor allele of each marker.2Minor allele frequency calculated in the sample of the previous study [16].3Minor allele frequency reported for Caucasians in the HapMap CEU.4Minor allele frequency calculated based on imputed genotypes.5The direction of the effects for the SNP, rs3091309, is the same in the previous study as in the GWAS sample according to the imputation results, where carriers of the minor allele ��A�� tend to have a lower AAM as compared with the non-carriers. Using Fisher's method [29] to combine the two p values achieved in the previous and the current GWAS samples, a p value of 4.78��10?3 is obtained for the overall association of this SNP with AAM in the two datasets.