Data from : From early development to maturity: A phenotypic analysis of the Townes sickle cell disease mice

Well-characterized mouse models of disease may provide valuable insights into pathophysiology. This study characterizes the Townes mouse model of sickle cell disease (SCD) and establishes a time window in which the disease is present but does not progress significantly in terms of severity.
We examined Townes mice with the HbAA, HbAS, and HbSS genotypes from young (4 weeks) to mature (5 months) stages of life to assess the disease state at different ages and any progression. We conducted blood tests, histological organ damage evaluations, and metabolic assessments to identify a suitable time frame for study based on welfare considerations.
Townes HbSS mice displayed key SCD features such as anaemia, haemolysis, thromboinflammation and organ pathology. Notably, these manifestations remained relative stable over the study period, indicating a stable phase suitable for conducting intervention studies. Mice with HbAS and HbAA genotypes served as comparative controls, showing minimal to no p..., , , # Data from : From early development to maturity: A phenotypic analysis of the Townes sickle cell disease mice

[https://doi.org/10.5061/dryad.m0cfxppdr](https://doi.org/10.5061/dryad.m0cfxppdr)

## Description of the data and file structure

Data was collected from in vivo studies on the Townes mouse model of Sickle cell disease and AI-based algorithms to classify liver H&E tissue sections. Raw data obtained from mouse in vivo experiments and AI-trained liver tissue classifier

### Files and variables

## File: Dataset.csv

**Description:** Raw in vivo data.

.csv: Utilized for organizing and presenting data summaries by genotype, month and sex. Each .csv file is part of a different type of parameters analysed:

* Haematological parameters: All blood related parameters
* HE: hematoxilin & eosin liver staining, tissue classifier outputs
* IHC: Immunohistochemistry of  P-selectin and von Willebrand Factor (vWF) in liver and lung
* Thrombogram: of each individual sample over time
...