Single-nucleus transcriptomic profiling of multiple organs from rhesus macaque model with SARS-CoV-2 infection

Here we profiled about 77000 single-nucleus transcriptomes of lung, liver, kidney, and cerebral cortex from rhesus macaques infected with SARS-CoV-2. Our work of multi-organ single-nucleus transcriptomic survey of SARS-CoV-2 infected animal model expanded our understanding of disease features and antiviral immune defects caused by the novel coronavirus at cellular and molecular level, which may facilitate the development of potential therapeutic intervention for COVID-19. Single-nucleus RNA-seq with lung, liver, kidney, cerebral cortex from two infected macaques as well as one or two healthy control. 10X Genomics platform was applied.