Alanine scanning mutagenesis of the NS3/4A cleavage sequences.
收藏Figshare2015-12-02 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_Alanine_scanning_mutagenesis_of_the_NS3_4A_cleavage_sequences_/316919
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Alanine scanning mutagenesis was used to systematically substitute amino acid residues at the P6–P4′ positions of the NS3-NS4A (1652DLEVVT↓STWV1661), NS4A-NS4B (1706DEMEEC↓SQHL1715), NS4B-NS5A (1967ECTTPC↓SGSW1976) and NS5A-NS5B (2415EDVVCC↓SMSY2424) junctions. Peptides were then cleaved NS3/4A. Two series of the 8-residue peptides were tested: the peptides which corresponded to the P6–P2′ and to the P4–P4′ positions. Only Z-scores above 3 are shown. Minus indicates Z-scores below 3.
创建时间：
2015-12-02
