Formal Synthesis of (±)-Platensimycin
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https://figshare.com/articles/dataset/Formal_Synthesis_of_Platensimycin/3011212
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资源简介：
Reductive alkylation of 5-methoxy-1-tetralone (6) with 2,3-dibromopropene gave an equilibrium mixture of bicyclic diones 7 (51%) and 8 (35%).
Radical cyclization of 7 afforded tricyclic dione 5 (84%), which was reduced, cyclized, and dehydrated to give tetracyclic alkene 13 in 63%
yield. Allylic oxidation of 13 with SeO2 and activated MnO2 afforded enone 2 in 85% yield, thereby completing a short formal synthesis of
(±)-platensimycin.
创建时间：
2007-04-26
