Testicular germ cell tumors (TGCTs) respond well to cisplatin-based therapy. However, cisplatin resistance and poor outcomes do occur. It has been suggested that a shift toward DNA hypermethylation me
Epidermal growth factor receptor kinase is implicated in cancer development due to either overexpression or activation variants in its functional intracellular kinase domain. Threonine to methionine (
The study is to analyze acquired genetic changes in the transition state of BLU-667-resistant cells in order to understand molecular mechanisms of residual tumors in their transition to resistance to
Additional file 9: Supplemental Figure 4. circPLPP4 confers CDDP resisitance of CDDP in OC cells. (A) qRT-PCR analysis of circPLPP4 and PLPP4 expression in the indicated OC cells. (B, C) MTT cell viab
Hydroxychloroquine (HCQ) and chloroquine are repurposed drugs known to disrupt autophagy, a molecular recycling pathway essential for tumor cell survival, chemotherapeutic resistance, and stemness. We