Data from: In diverse conditions intrinsic chromatin condensate have liquid-like material properties
收藏DataCite Commons2025-05-01 更新2025-05-10 收录
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https://datadryad.org/dataset/doi:10.5061/dryad.83bk3j9ws
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资源简介:
The organization of eukaryotic chromatin is important in many nuclear
processes. Recent studies have shown that chromatin fragments can
self-assemble by phase separation into micron-scale structures in the
presence of salt in vitro. There are discrepancies regarding
whether these structures generally have liquid-like or solid-like
behaviors, an important distinction in considering how processes such as
transcription and chromosome remodeling by loop extrusion can occur in
cells. Here, we resolve conflicting reports by demonstrating that
chromatin condensates have liquid-like behaviors in diverse solution
conditions and describing aspects of sample handling that can lead to
artifactual solid-like behaviors. Our data suggest how chromatin can be
dynamic on short length scales but restrained on long length scales, as
observed in cells.
提供机构:
Dryad
创建时间:
2023-04-25



