Lipid compositions for all the bilayersa used in the present work.

aThe subscripts “MD” refer to the systems studied only by regular (unbiased) molecular dynamics simulations, thus they were not used in free energy calculations. The subscripts “FE” refer to the systems used for free energy calculations. Lo and Ld stand for liquid-ordered and liquid-disordered phases, respectively.bArea per lipid calculated by dividing the time averaged total area of each simulation system by the number of lipids per leaflet.The numbers of each lipid in a given system, the phase, and the area per lipid are indicated.Lipid compositions for all the bilayersa used in the present work.