Plasma and tumour tissue concentration AUC values following GDC-0941 and PD 0325901 administration.

Figure 1). The area under the curve (AUC) was calculated and data are presented are the mean AUC ± standard deviation. Significant differences between groups are denoted by superscript letters; a,c,d,f pb,g,j p = 0.04, e,h p = 0.01, i p = 0.02. Plasma and tumour tissue concentrations of the PI3K inhibitor GDC-0941 and the MEK inhibitor PD 0325901 were measured by HPLC in samples from HCT116 tumour xenograft-bearing mice over 24 hours after a single p.o. dose of 10 or 100 mg/kg GDC-0941 or 1 or 10 mg/kg PD 0325901, alone and in combination (