Supplementary datasets for: Integrated metabolomics and network pharmacology to decipher habitat-driven metabolic diversity and α-glucosidase inhibitory mechanisms in guava leaves

This dataset contains all supplementary data files (Supplementary Data S1–S6) supporting our study on the chemical profiling, bioactive marker prioritization, and network pharmacology analysis of Psidium guajava. The contents of the individual files are as follows: - Supplementary Data S1: Raw quantitative data for total phenolic content (TPC), total flavonoid content (TFC), antioxidant capacity (ABTS), and α-glucosidase inhibition, along with Pearson correlation analysis across different origins. - Supplementary Data S2: Comprehensive phenolic metabolomics dataset, including the full list of 1,230 phenolic features, 753 differentially accumulated metabolites (DAMs), and 147 prioritized candidate bioactives. - Supplementary Data S3: Disease-related target set retrieved from GeneCards and OMIM databases, and the 226 overlapping intersection targets between bioactive compounds and disease targets. - Supplementary Data S4: Predicted target profiles for the candidate bioactive compounds obtained via SwissTargetPrediction. - Supplementary Data S5: Protein-protein interaction (PPI) network topological parameters (degree, betweenness centrality, and closeness centrality) and screened core target nodes. - Supplementary Data S6: Full output tables for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analyses.