Genetic evidence that the RAG1 protein directly participates in V(D)J recombination through substrate recognition.
收藏PubMed Central1996-03-19 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC39796/
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资源简介：
RAG1 protein is essential for the activation of V(D)J recombination in developing lymphocytes (V, variable; D, diversity; J, joining). However, it has not been determined whether its role involves substrate recognition and catalysis. A single amino acid substitution mutation in the RAG1 gene has now been identified that renders its activity sensitive to the sequence of the coding region abutting the heptamer site in the recombination signal sequence. These results strongly imply that RAG1 interacts directly with DNA. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-03-19
