Expression data from mammary epithelia and mammary fibroblasts from mice with and without epithelial KrasG12D and with and without stromal p53 deletion
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE201935
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p53 is a known tumor suppressor. We have found that stromal p53 regulates breast cancer development, the immune landscape, and survival in an oncogene specific manner when comparing the epithelial oncogenes ErbB2 and KrasG12D In this dataset, we have evaluated mammary epithelia from mice with and without epithelial KrasG12D and with and without stromal p53 deletion. We have also evaluated mammary fibroblasts from mice with and without epithelial KrasG12D and with and without stromal p53 deletion. 32 total samples were analyzed. 16 epithelial cell isolates and 16 fibroblast isolates (4 biological replicates for each condition - with or without epithelial KrasG12D and with or without fibroblast p53 deletion using FspCre and p53fl/fl alleles)
创建时间:
2022-08-01



