Additional file 1 of Prognostic value of functional SMAD4 localization in extrahepatic bile duct cancer

Additional file 1: Supplemental Figure 1. Histogram of the SMAD4 immunohistochemical score for resected specimens. Supplemental Figure 2. Kaplan-Meier survival curves for 67 patients with SMAD4 expression at either the central lesion or invasion front stratified by the SMAD4 status in each area. Supplemental Figure 3. Kaplan-Meier survival curves for 73 patients who underwent upfront surgery stratified by treatment with adjuvant chemotherapy. Supplemental Figure 4. Kaplan-Meier survival curves for patients who underwent upfront surgery stratified by treatment with adjuvant chemotherapy. Supplemental Figure 5. Kaplan-Meier survival curves for patients who underwent upfront surgery stratified by treatment with adjuvant chemotherapy. Supplemental Figure 6. Kaplan-Meier survival curves for 98 patients stratified by neoadjuvant treatment.