In the relative hand skill GWAS meta-analysis of individuals with reading disability, there is an over-representation of highly associated SNPs within human orthologs of genes involved in causing LR asymmetry phenotypes when knocked out in mice.

15 phenotypes that contain between 10 and 100 genes, and cause asymmetry defects when knocked out in mice, were tested using MAGENTA (see Materials and Methods). The observed number of genes were compared to the expected using a cut-off that equals the 75th percentile of all gene P values. P values were then adjusted for multiple testing using an FDR correction.