Cell Death Proteomics Database: Consolidating Proteomics Data on Cell Death

Programmed cell death is a ubiquitous
process of utmost importance
for the development and maintenance of multicellular organisms. More
than 10 different types of programmed cell death forms have been discovered.
Several proteomics analyses have been performed to gain insight in
proteins involved in the different forms of programmed cell death.
To consolidate these studies, we have developed the cell death proteomics
(CDP) database, which comprehends data from apoptosis, autophagy,
cytotoxic granule-mediated cell death, excitotoxicity, mitotic catastrophe,
paraptosis, pyroptosis, and Wallerian degeneration. The CDP database
is available as a web-based database to compare protein identifications
and quantitative information across different experimental setups.
The proteomics data of 73 publications were integrated and unified
with protein annotations from UniProt-KB and gene ontology (GO). Currently,
more than 6,500 records of more than 3,700 proteins are included in
the CDP. Comparing apoptosis and autophagy using overrepresentation
analysis of GO terms, the majority of enriched processes were found
in both, but also some clear differences were perceived. Furthermore,
the analysis revealed differences and similarities of the proteome
between autophagosomal and overall autophagy. The CDP database represents
a useful tool to consolidate data from proteome analyses of programmed
cell death and is available at http://celldeathproteomics.uio.no.