Genome-Wide Identification of Nucleotide Variants Associated with Antimicrobial Resistance in Mycoplasma bovis

An investigation of 18 separate GWAS on 194 M. bovis genomes was performed, with the objective being to associate antimicrobial resistant phenotypes to variability within genetic determinants linked to antimicrobial resistance. A total of nine antimicrobials spanning the four commonly administered antimicrobial classes in feedlot cattle were used: fluoroquinolones (enrofloxacin), tetracyclines (oxytetracycline, and chlortetracycline), phenicols (florfenicol), and macrolides (gamithromycin, tildipirosin, tilmicosin, tulathromycin, and tylosin tartrate).