MeRIP-sequencing analysis of cerebral cortex in Down syndrome and controls

To explore the characteristics of m6A RNA modification in the Down syndrome brain, we collected cerebral cortex tissues of the fetuses diagnosed with Down syndrome and controls respectively, and performed an optimized methylated RNA immunoprecipitation combined with deep sequencing (MeRIP-seq). Three of cortex tissues from Down syndrome fetus and two of cortex tissues from controls were used to identify the characteristics of m6A RNA modification in the Down syndrome brain and differential expressed m6A related genes in Down syndrome