Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

The dataset contains the repertoire sequencing data from 45 adult volunteers.For
each case 4 separate TCR repseq libraries were constructed after cDNA
synthesis using a UMI containing primer located in the constant exon of
the TRA, TRD, TRB and TRG genes respectively. In each case a 5’
multiplex set of primers specific for the leader regions of the V genes
of either TRA, TRD, TRB or TRG genes was used along with a universal
reverse primer, introduced during the cDNA synthesis step to produce the
gene specific repseq library.The
libraries were sequenced using the Illumina 2 x 300 cycle MiSeq system
at the Karlsson Hedestam Laboratory at the Department of Microbiology,
Tumor and Cell Biology at Biomedicum, Karolinska Institutet, Stockholm. <br><br><b>Terms for access</b>The
datasets are only to be used for research that is seeking to advance
the understanding of the influence of TCR genetic variation on human
biology.<br><br>