Effect of a PDD on oxaliplatin-induced mechanical and cold hypersensitivity.

Rats were fed with a normal diet (triangles) or a PDD (circles) for 7 days before the beginning of the tests and through to the end of the experiment. At day 0, after measuring baseline mechanical pain thresholds, rats were injected with oxaliplatin (6 mg/kg, i.p., OXA, black symbols) or vehicle (CT, white symbols). (A) Mechanical pain hypersensitivity expressed as paw withdrawal threshold (gram). (B) Cold hypersensitivity (12°C vs. 25°C) expressed as time spent on the cold plate (%). Two-way repeated-measures ANOVA followed by a Tukey-Kramer post hoc test. *, p<0.05; **, p<0.01; ***, p<0.001 for normal diet - OXA vs. normal diet - CT; ¤¤, p<0.01; ¤¤¤, p<0.001 for normal diet - OXA vs. PDD - OXA. All data are expressed as means ± SEM (n = 6 to 12 per group).