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Foxp3+ regulatory T cells control psoriasiform skin inflammation by restraining a type 1 interferon driven CD8+ T cell response

ChEBI2018-06-24 更新2026-07-12 收录

银屑病免疫机制

调节性T细胞功能

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-6873 数据链接链接失效反馈

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资源简介：

Foxp3+ regulatory T cells control psoriasiform skin inflammation by restraining a type 1 interferon driven CD8+ T cell response

应用场景：

创建时间：

2018-06-24

调节性T细胞功能

转录调控机制

We investigated the role of Ikaros in regulatory Tcell identity and function during stimulation using RNA-seq, ATAC-seq, and H3K27ac/Foxp3/Ikzf1 ChIP-seq Overall design: We performed ATAC-seq, RNA-seq

NIAID Data Ecosystem80

Transcription profile of WT and LKB1 (encoded by the gene Stk11)-deficient Treg cells. Mus musculus

调节性T细胞功能

免疫细胞转录组学

LKB1 deficiency in Treg cells impairs their survival, metabolism and suppressive function. To exclude the impact of excessive inflammation on LKB1-deficient Treg cells, we generated mixed bone marrow

NIAID Data Ecosystem50

Global Mapping of H3K4me1 and H3K4me3 in human CD4+CD25+FOXP3+ Treg cells. Homo sapiens

表观遗传调控

调节性T细胞功能

Regulatory T cells (Treg) contribute to the crucial immunological processes of self-tolerance and immune homeostasis. However, the mechanisms underlying Treg function and cell fate decisions to differ

NIAID Data Ecosystem20

Upregulation of BTN3A1 on CD14+ cells promotes Vγ9Vδ2 T cells activation in psoriasis vulgaris. Upregulation of BTN3A1 on CD14+ cells promotes Vγ9Vδ2 T cells activation in psoriasis vulgaris

银屑病免疫机制

T细胞调控

Vγ9Vδ2 T cells play an important role in the development and progression of psoriasis vulgaris (PV), but how they promote skin inflammation and the molecular mechanisms underlying Vγ9Vδ2 T cell dysfun

NIAID Data Ecosystem60

Human Regulatory T Cell Suppressive Function Is Independent of Apoptosis Induction in Activated Effector T Cells

调节性T细胞功能

自身免疫疾病机制

BackgroundCD4+CD25+FOXP3+ Regulatory T cells (Treg) play a central role in the immune balance to prevent autoimmune disease. One outstanding question is how Tregs suppress effector immune responses in

NIAID Data Ecosystem40

Foxp3+ regulatory T cells control psoriasiform skin inflammation by restraining a type 1 interferon driven CD8+ T cell response

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