Genetic surexpression of human BIN1 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)

In this study, we performed RNA sequencing on tibialis anterior muscle of male mice at 7 weeks of age. WT and Mtm1 deficient (Mtm1-/y) mice were sequenced. The rescued mice, Mtm1-/y mice crossed with TgBIN1 mice (Mmt1-/yTgBIN1) and the associated control mice TgBIN1 were also sequenced. The study is composed of 4 groups of mice: WT, Mtm1-/y, TgBIN1 and Mtm1-/yTgBIN1. Each group was composed from triplicates to quadruplicates. The comparison of transcriptome profiles across the different genotypes was assessed in this study.