One-Pot Synthesis of 3‑Substituted 2‑Arylpyrrole in Aqueous Media via Addition–Annulation of Arylboronic Acid and Substituted Aliphatic Nitriles

Pd­(II)-catalyzed
C–C coupling reactions between substituted
aliphatic nitriles and arylboronic acids followed by in situ cyclodehydration
have been employed for the first time to synthesize a wide variety
of 3-substituted 2-aryl-1H-pyrroles in aqueous acetic
acid. This one-pot synthesis is green, and it conforms to atom economy.
The structures of two representative pyrroles, 3k and 5f, were confirmed by X-ray crystallographic analysis.