Enantioselective Conjugate Addition of N,N-Dialkylhydrazones to α-Hydroxy Enones‡
收藏Figshare2007-07-19 更新2026-04-28 收录
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https://figshare.com/articles/dataset/Enantioselective_Conjugate_Addition_of_i_N_i_i_N_i_-Dialkylhydrazones_to_-Hydroxy_Enones_sup_sup_/12066849
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The activation of α-hydroxy enones by the Zn(OTf)2/tBuBOX catalyst enables the enantioselective conjugate addition of 1-methyleneaminopyrrolidine as a neutral d1 synthon. Experimental evidence supports a stereochemical model where a triflate ligand controls the geometry of the catalyst−substrate complex by means of a OH−OTf hydrogen bond. The synthesis of β-cyano acids illustrates the potential of the methodology.
创建时间：
2007-07-19
