microarray in SCLC transformation

The histological transformation of lung adenocarcinoma (LUAD) to an aggressive neuroendocrine (NE) derivative resembling SCLC is a signature example of lineage plasticity in cancer.But the changes of gene expression need to be studied. We used microarrays to detail the global programme of gene expression under transformation and reversed transformation cells and identified distinct classes of up-regulated genes during this process. we performed Affymetrix microarrays in Transformation-cells (T), Reversed cells (RT) and Parental cells (P)