Overview of HLA class I and II restriction molecules, obstetric and family history, male microchimeric cell types and HLA class I and II HY-specific T regulator cells.

G* = Pregnancies enduring more than 16 weeks of gestational age;
@inhibition of tetanus toxoid recall antigen induced footpad swelling in the presence of the relevant HY peptide measured in the tvDTH assay; donors displaying ≥50% reduction are defined as DTH regulator phenotype [7].
(H) = homozygous; TB = twin brother; mDC = myeloid dendritic cells, gran = granulocytes, T = T cells, B = B cells, M = monocytes.
†≥1 early miscarriage (6–12 weeks of gestational age);
#miscarriage at 24 weeks (male fetus);
∧elective abortion at 5 weeks; Δ elective abortion at 12 weeks.
nt = not tested.
‡tested against a single HLA-A2/HY peptide instead of the HYclass-I peptide pool and another self minor Histocompatibility peptide instead of the HX peptide pool.
•excluded from Figure 3 on the basis of an unexplained profoundly suppressed swelling response in the presence of the control HXclass-I+II peptide pool.
HYclass-I: HLA-A1/HY, HLA-A2/HY, HLA-B7/HY, HLA-B8/HY, HLA-B60/HY; HYclass-II: HLA-DRB3*0301/HY, HLA-DR15/HY, HLA-DQ5/HY; HXclass-I+II: HLA-A1/HX, HLA-A2/HX, HLA-B7/HX, HLA-B8/HX, HLA-B60/HX, HLA-DRB3*0301/HX, HLA-DR15/HX, HLA-DQ5/HX.