Summary of DNA binding activity, EBV lytic gene activation, and DNA damage signaling phenotypes of ZEBRA mutants compared to wild-type ZEBRA.

Capacities for DNA binding and activation of EBV lytic genes by WT and mutant ZEBRA were determined previously [48]. Generation of pATM foci was determined by immunofluorescence assays, in 293 cells, as described in Fig 11.+ denotes proficiency, relative to WT, in performing the respective activity.- denotes deficiency, relative to WT, in performing the respective activity.Summary of DNA binding activity, EBV lytic gene activation, and DNA damage signaling phenotypes of ZEBRA mutants compared to wild-type ZEBRA.