Genome-wide association studies of the kynurenine pathway

This repository contains GWAS summary statistics of metabolites of the kynurenine pathway and related metabolite ratios. They were derived from the NHUSK cohort. Details on the model constructed and covariables accounted for can be consulted in the follwing publication. Genome Wide Association Study of the Kynurenine Pathway Chinh B’krong Nguyen, Arve Ulvik, Tore Ivar Aarsland, Adrian McCann, Øyvind Helgeland, Grethe Seppola Tell, Rolv T Lie, Ottar Nygård, Per Magne Ueland, Pål Rasmus Njølstad, Jan Haavik, Stefan Johansson For details on the methods and affiliations, please consult the original publication. Content: The table shows an overview of the summary statistics files relevant for the study. Variables Biochemical name Unit measure Summary statistics file name AA Anthranilic acid nmol/L assoc_Cov_BMI_SMK_Creat_C.AA_D.assoc.linear_extracted.gz HAA Hydroxyanthranilic acid nmol/L assoc_Cov_BMI_SMK_Creat_C.HAA_D.assoc.linear_extracted.gz HK Hydroxykynurenine nmol/L assoc_Cov_BMI_SMK_Creat_C.HK_D.assoc.linear_extracted.gz KA Kynurenic acid nmol/L assoc_Cov_BMI_SMK_Creat_C.KA_D.assoc.linear_extracted.gz Kyn Kynurenine µmol/L assoc_Cov_BMI_SMK_Creat_C.Kyn_D.assoc.linear_extracted.gz Pic Piconilic acid nmol/L assoc_Cov_BMI_SMK_Creat_C.Pic_D_2017.assoc.linear_extracted.gz QA Quinolinic acid nmol/L assoc_Cov_BMI_SMK_Creat_C.QA_D_2017.assoc.linear_extracted.gz Trp Tryptophan µmol/L assoc_Cov_BMI_SMK_Creat_C.Trp_D.assoc.linear_extracted_no_ci.gz XA Xanthurenic acid nmol/L assoc_Cov_BMI_SMK_Creat_C.XA_D.assoc.linear_extracted.gz Ratios Clinical relevance Ratio Calculation Summary statistics file name Kyn/Trp (KTR) Inflammaging 1000Kyn/Trp assoc_95CI.Kyn_Trp.assoc.linear_extracted.gz KA/QA Neuro-modulation KA/QA assoc_95CI.KA_QA.assoc.linear_extracted.gz Pic/QA Neuro-modulation Pic/QA assoc_95CI.Pic_QA.assoc.linear_extracted_no_ci.gz Kyn/KA Neuro-modulation Kyn/KA assoc_95CI.Kyn_KA.assoc.linear_extracted.gz HKr_a Vitamin B6 HK/(KA+XA) assoc_95CI.HK_KAXA.assoc.linear_extracted.gz HKr_b Vitamin B6 HK/(AA+HAA) assoc_95CI.HK_HAAAA.assoc.linear_extracted.gz HKr Vitamin B6 HK/(KA+AA+XA+HAA) assoc_95CI.PLP_avail.assoc.linear_extracted.gz