five

Crystal Structure of human JMJD2D complexed with KDOPP7

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Protein Data Bank Japan2024-01-10 更新2026-03-21 收录
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Crystal Structure of human JMJD2D complexed with KDOPP7 Descriptor: 1,2-ETHANEDIOL, 8-[[(phenylmethyl)amino]methyl]-1~{H}-pyrido[3,4-d]pyrimidin-4-one, Lysine-specific demethylase 4D, ... Authors: Krojer, T, Vollmar, M, Crawley, L, Bradley, A.R, Szykowska, A, Ruda, G.F, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-12-04 Release date: 2015-12-30 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.88 Å) Cite: 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
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2015-12-04
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