GPR120 impairs the anti-tumor functionality of CD8+ T cells in the HCC immune microenvironment. (PRJCA042897)

We conducted transcriptomic sequencing analysis on primary hepatocellular carcinoma (HCC) tissues from hepatocyte-specific GPR120 knockout mice and their control counterparts, followed by an in-depth investigation into its regulatory mechanisms in shaping the tumor microenvironment (TME).