Intermediate filaments are regulators organismal lifespan in C. elegans
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE193444
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Purpose: Try to find out whether germline loss retards the normal somatic aging Methods: Employed transcriptome analysis in both young and aged germline-deficient animals and identified genes that are normally decreased during aging in wild-type (WT) worms but are well maintained in aged germline-deficient animals Results: Compared with D1, there were 1834 genes downregulated at D6, while only 441 genes showed increased expression Wild type Caenorhabditis elegans and glp-1 mutants are 25°C-cultivated to the D1 adult , and keep at 20°C to D6. Then total mRNA profiles were generated by deep sequencing, in triplicate, using Illumina NovaSeq 6000
创建时间：
2023-12-30
