Correlations between haplotype conservation and the CD8+ T lymphocyte phenotype in chromosomes of HH patients from Porto (n = 128), Alabama (n = 112) and Nord-Trøndelag (n = 362).

The percentage (case/total numbers) of patients with CD8+ T lymphocytes below the 25% percentile (“low CD8 phenotype”) are indicated followed by the mean (±standard deviation) of CD8+ T lymphocyte counts (x103/ml) for each haplotype combination.(P) Statistical significant differences among the 3 populations of patients (using the Chi-square test or One-way ANOVA, as appropriate, see M&M).(*) Results significantly lower (p(**) Result significantly lower than the respective control due to a small (n = 5) founder group of HLA-A*01 patients. The statistical significance is lost if this group is excluded.