CUTANEOUS BLOOD CIRCULATION IN THE PATHOPHYSIOLOGY OF SKIN INFLAMMATION

Skin inflammation is a multifactorial biological phenomenon characterized by complex interactions among vascular, immune, and structural components of the integumentary system. Microcirculatory alterations constitute one of the earliest and most significant manifestations of inflammatory responses in the skin. These vascular changes regulate immune cell trafficking, tissue perfusion, and metabolic adaptation. This article provides a comprehensive overview of cutaneous circulation during inflammation, focusing on vascular physiology, endothelial dynamics, leukocyte recruitment, angiogenesis, and clinical implications.