Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting

The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled the release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging  ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease.  Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy., , , # Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting

[DOI:10.5061/dryad.np5hqc04q](https://doi.org/10.5061/dryad.np5hqc04q)

## Description of the data and file structure

This dataset contains diverse data types and analyses, including from chemical synthesis, enzyme kinetics, murine models, pharmacokinetics, and metagenomics.  Please see the published article for full experimental details, final data presentation, and interpretations.

Files are organized into compressed archives, first by overall analysis type, and then by corresponding figure in the published article.

### File: CompoundNMR.7z

Contains original free-induction decay (FID) spectra and acquisition parameters for all one- and two-dimensional nuclear magnetic resonance (NMR) analyses of synthetic compounds. Within this archive, sub-archives contain data corresponding to Figures S16-S27, as indicated in the filenames: FigS16_FID_PerAcXXXX-OH.7z, FigS17_FID_PerAcXXXG-TCA.7z, FigS18_FID_PerAcXXXG-De...,