Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13153
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Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13153 Descriptor: 2-(2-cyclopentyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-5-methyl-furo[3,2-c]pyridin-4-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... Authors: Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. Deposit date: 2022-01-13 Release date: 2022-08-10 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
创建时间：
2022-01-13
