Gene expression profile at single cell level of isogenic iPSC-derived primitive erythroblasts (RBCs), iPSC-derived definitive RBCs and Fetal liver-derived RBCs

In this study, we generated and validated in vitro models to study human embryonic and fetal erythropoiesis using induced pluripotent stem cells (iPSCs). Overall design: We used distinct differentiation protocols to generate pure embryonic or fetal RBCs from iPSCs and compared them with genetically matched isogenic erythroid cells from a primary fetal liver