Hijacking the miR-200a&c–Jagged1 Negative Feedback Loop Attenuates Angiostrongylus cantonensis-Induced Demyelinating Optic Neuritis via Notch Suppression

This dataset supports the research article "Hijacking the miR-200a&c–Jagged1 Negative Feedback Loop Attenuates Angiostrongylus cantonensis-Induced Demyelinating Optic Neuritis via Notch Suppression". It contains:• miRNA and mRNA microarray data from mouse corpus callosum• qRT-PCR validation data for miR-200a&c and Notch pathway genes• Western blot protein expression data for Jagged1, Notch signaling components• Visual electrophysiology (VEP/ERG) recordings• Histopathology images (H&E, LFB staining)• Electron microscopy images of myelin ultrastructure• Immunofluorescence images of retinal ganglion cells and myelin• Primary oligodendrocyte precursor cell viability data• Dual-luciferase assay results validating miR-200a targeting of Jagged1The data demonstrate how parasitic infection disrupts neural feedback homeostasis and the therapeutic potential of miRNA intervention. Data are organized by figure panels from the associated publication.