Two Ewing's sarcoma cell lines were evolved in the standard chemotherapy treatment given to patients. After each dose of chemotherapy treatment, drug sensitivity profiles were captured on each cell li
This study identifies phosphorylation of SHP2 at tyrosine 62 (pY62) as a conserved mechanism of resistance to allosteric SHP2 inhibitors. By stabilizing an open, active SHP2 conformation, pY62 phenoco
Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid,
