Genome-wide analysis of osteosarcoma for comparison to healthy bone tissue
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https://www.ncbi.nlm.nih.gov/sra/SRP360913
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资源简介：
Analysis of common pediatric osteosarcoma cell lines SaOS2, U2OS and 143B and two patient derived xenograft samples in comparison of osteoblast cell line hFOB1.19. Overall design: Pediatric osteosarcomas (OS) exhibit extensive genomic instability that has complicated the identification of new targeted therapies. Here we report that the vast majority of 108 patient tumor samples and patient-derived xenografts (PDXs), which display an unusually dilated endoplasmic reticulum (ER) haver reduced expression of four COPII vesicle components that trigger aberrant accumulation of procollagen-I protein within the ER. OS cell lines were used as an experimentally tractable system. Total RNA obtained from cells and tumor tissue of PDXs
创建时间：
2022-04-20
