Antibiotic resistance genes modulation by Neolamarckia cadamba leaves extract in cecum and feces of LPS-induced broilers.

Antibiotics are always banned to use in livestock production because of the threat of antimicrobial resistance. As alternatives, plant extract containing bioactive substances are increasingly used to improve immunity and promote productivity. However, little is known about their effects on diversity, abundance of antibiotic resistance genes (ARGs). Here, we investigated the effects of Neolamarckia cadamba leaves extract, with effective ingredients of flavonoids, on ARGs and relevant microorganisms in cecum and feces of broilers treated with or without lipopolysaccharide stimulation. Further studies are necessary to evaluate the effect of plant extract on diversity, abundance, and dissemination of ARGs in feces of farm animals.