tne_ewas_mec_race_ethnicity_meta_analysis.zip

Summary statistics for the discovery meta-analysis epigenome-wide association study (EWAS) of total nicotine equivalents (TNE) in the Multiethnic Cohort Study (meta-analysis of five race- and ethnicity-specific EWAS: African American, European American, Japanese American, Latino, Native Hawaiian). Results from each race- and ethnicity-specific EWAS are included as additional columns. Estimates from the models represent the change in methylation β-value per one log-unit increase in TNE.Column descriptions:<b>probe_id: </b>CpG probe ID<b>chr:</b> Chromosome containing the CpG (Build 37)<b>mapinfo: </b>Chromosomal coordinates of the CpG (Build 37)<b>strand: </b>The Forward (F) or Reverse (R) designation of the Design Strand<b>gene: </b>Target gene names, from the UCSC database<b>gene_group:</b> Gene region feature category describing the CpG position, from UCSC. Features are listed in the same order as the target gene transcripts<b>meta_est:</b> Parameter estimate for the race and ethnicity meta-analyzed association between TNE and DNA methylation<b>meta_se:</b> Standard error of the parameter estimate for the race and ethnicity meta-analyzed association between TNE and DNA methylation<b>meta_p: </b>P-value for the race and ethnicity meta-analyzed association between TNE and DNA methylation<b>meta_direction: </b>The direction (positive or negative) of the race- and ethnicity-specific parameter estimates for African Americans, European Americans, Japanese Americans, Latinos, and Native Hawaiians, respectively<b>meta_het_i_sq: </b>The heterogeneity I² statistic for the race and ethnicity meta-analysis across the five racial and ethnic groups<b>meta_het_p: </b>The heterogeneity p-value for the race and ethnicity meta-analysis across the five racial and ethnic groups<b>aa_est:</b> Parameter estimate for the African American-specific association between TNE and DNA methylation<b>aa_se:</b> Standard error of the parameter estimate for the African American-specific association between TNE and DNA methylation<b>aa_p:</b> P-value for the African American-specific association between TNE and DNA methylation<b>ea_est:</b> Parameter estimate for the European American-specific association between TNE and DNA methylation<b>ea_se:</b> Standard error of the parameter estimate for the European American-specific association between TNE and DNA methylation<b>ea_p: </b>P-value for the European American-specific association between TNE and DNA methylation<b>ja_est:</b> Parameter estimate for the Japanese American-specific association between TNE and DNA methylation<b>ja_se: </b>Standard error of the parameter estimate for the Japanese American-specific association between TNE and DNA methylation<b>ja_p:</b> P-value for the Japanese American-specific association between TNE and DNA methylation<b>l_est: </b>Parameter estimate for the Latino-specific association between TNE and DNA methylation<b>l_se:</b> Standard error of the parameter estimate for the Latino-specific association between TNE and DNA methylation<b>l_p:</b> P-value for the Latino-specific association between TNE and DNA methylation<b>nh_est:</b> Parameter estimate for the Native Hawaiian-specific association between TNE and DNA methylation<b>nh_se:</b> Standard error of the parameter estimate for the Native Hawaiian-specific association between TNE and DNA methylation<b>nh_p:</b> P-value for the Native Hawaiian-specific association between TNE and DNA methylation