Lactobacillus reuteri protects Parkinsons disease model mice

Parkinsons disease (PD) is a prevalent neurodegenerative disorder characterized by gastrointestinal (GI) and motor dysfunctions, with limited treatment options available. Emerging evidence has implicated the involvement of gut microbiota dysbiosis in PD pathogenesis. As an approach to balancing the gut microbiome, probiotics have exerted potential health benefits to PD. Here, we systematically evaluate the therapeutic potential of the probiotic Lactobacillus reuteri (L. reuteri) supplementation in a rotenone-induced PD mouse model and elucidate the underlying mechanisms.