Notch signaling between cerebellar granule cell progenitors. Notch signaling between cerebellar granule cell progenitors

During cerebellar development, maternal granule cell progenitors (GCPs) divide to produce not only postmitotic granule cells (GCs) but also sister GCPs. However, molecular machinery to proportionally produce distinct sister cell types from seemingly uniform GCPs is still elusive. Here we report Notch signaling makes a difference among GCPs, leading to their proportional differentiation. Overall design: P7 cerebella cells were extrated using percoll density gradient centrifugation and further captured via the C1 Fluidigm systems with 96-well chips