Alzheimer's disease DNA (hydroxy) methylome in the brain: OXT methylation as a preclinical marker.

The present study investigated the DNA methylome and hydroxymethylome, as well as unmodified cytosine in relation to Alzheimer’s disease (AD). We identified epigenetic differences between AD patients and age-matched controls in the middle temporal gyrus, in genomic regions associated with genes such as OXT, ACSL1, RHBDF2, C3, and MIR9-3HG. Interestingly, we found that OXT methylation in the blood of aged, non-demented individuals is also associated with conversion to AD dementia. The current GEO records concerns the middle temporal gyrus (ox)BS-processed Illumina 450K dataset of this study. (Oxidative) Bisulphite converted DNA from 82 samples were hybridised to the Illumina HumanMethylation450 BeadChip.