Pre-Transplant Gut Dysbiosis Drives Enterobacteriaceae Dominance and Infection Risk After Intestinal Transplantation

Infections remain a major cause of morbidity and mortality after intestinal transplantation (ITx). The role of the recipient’s pre-existing gut microbiota in post-transplant outcomes is poorly understood. This study investigated whether pre-transplant dysbiosis, particularly Enterobacteriaceae overgrowth, serves as a reservoir for post-transplant infection and interacts with intraoperative stressors to amplify risk.