Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors
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https://figshare.com/articles/dataset/Discovery_of_the_First_Histone_Deacetylase_6_8_Dual_Inhibitors/2405227
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资源简介：
We
disclose the first small molecule histone deacetylase (HDAC)
inhibitor (3, BRD73954) capable of potently and selectively
inhibiting both HDAC6 and HDAC8 despite the fact that these isoforms
belong to distinct phylogenetic classes within the HDAC family of
enzymes. Our data demonstrate that meta substituents of phenyl hydroxamic
acids are readily accommodated upon binding to HDAC6 and, furthermore,
are necessary for the potent inhibition of HDAC8.
创建时间：
2016-02-19
