Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue

We investigate the role of resident memory T cells in protective immunity in HIV infection Funding sources: Michael R. Betts: NIH/NIAID R01 AI076066 and R01 AI118694 Marcus Buggert: Swedish Research Council (Dnr 537-2014-6829), Karolinska Institutet, Magnus Bergvall and Lars Hiertas Stiftelse Examination of resident memory T cell transcriptome and chromatin accessibility in lymph nodes. Examination of single-cell transcriptome and T cell receptor sequences of HIV-specific resident memory CD8+ T cells in lymph nodes. Bulk RNASeq and ATAC-Seq were performed on CD69+ and CD69- CD8+ T cells from human lymph nodes. Single cell RNASeq was performed on CD69+ and CD69- CD8+ T cells from human mesenteric lymph nodes.