RCOR2 downregulates CIITA via HDAC1-mediated histone deacetylation in cancer cells [ChIP-seq]
收藏NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP514313
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资源简介：
RCOR2 and HDAC1 directly co-binds to CIITA gene. RCOR2 knockout does not affect HDAC1 binding on CIITA gene. RCOR2 has no binding on most MHCII genes. Overall design: MDA-MB-231 cells overexpressing HA tagged RCOR2 were subjected to ChIP-seq with anti-HA antibody. Parental and RCOR2-KO MDA-MB-231 cells were subjected to ChIP-seq with anti-HDAC1 antibody. Occupancy of RCOR2 and HDAC1 on CIITA and MHCII genes were analyzed.
创建时间：
2026-02-07
